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KMID : 0387820090160020145
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Clinical Pediatric Hematology-Oncology
2009 Volume.16 No. 2 p.145 ~ p.150
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A Case of Chronic Active Epstein-Barr Virus Infection Progressed to Peripheral T-cell Lymphoma of Lung
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Yeon Gyu-Min
Kwon Kyung-Ah
Kwak Jeong-Won
Park Seong-Shik
Park Jae-Hong
Lim Young-Tak
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Abstract
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Chronic active Epstein-Barr virus (EBV) infection (CAEBV) is a nonfamilial syndrome that shows a specific immunodeficiency for EBV. The primary features of CAEBV are recurrent or chronic infectious mononucleosis-like symptoms, such as prolonged fever, hepatosplenomegaly, persistent hepatitis and extensive lymphadenopathy for > or =3 months. The chronic illness cannot be explained by other known disease processes at diagnosis, and there is no underlying immunological identifiable abnormalities. Patients with CAEBV have unusual pattern of anti-EBV antibodies with high antivirus-capsid-antigen (anti-VCA) and anti-early antigen (anti-EA), and/or detection of high EBV genome levels in the affected tissues, including peripheral blood. CAEBV often results in life-threatening complications and 18% of those is malignant lymphoma, but malignant lymphoma of lung is very rare. We present a case of CAEBV that progressed to peripheral T-cell lymphoma of lung in a 10-year-old boy.
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KEYWORD
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Chronic active Epstein-Barr virus infection, Epstein-Barr virus, Peripheral T-celllymphoma, Lung
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